| Ecosystem | Type | Status | Ref. |
|---|---|---|---|
| Chesapeake Bay | Sea/Bay/Gulf | Native | 93252 |
| Colorado River | River (basin) | native | 10294 |
| Great Lakes | Lake | native | 4639 |
| Mississippi River | River (basin) | native | 10294 |
| Missouri River | River (basin) | native | 78789 |
| Nearctic | Zoogeographic realm | endemic | 1998 |
| St. Lawrence | River (basin) | native | 5723 |
| Susquehanna River | River (basin) | native | 86798 |
| Tennessee River | River (basin) | native | 10294 |
| Waccamaw | Lake | native | 35360 |